Abstract Dense single nucleotide polymorphism (SNP) panels are widely used for genome-wide association studies (GWAS).In these panels, SNPs within a genomic segment tend to be highly correlated.Thus, association studies based on testing the significance of single SNPs are not very effective, and genomic-window based tests have been Gas Cooker proposed to address Crawl Tunnels this problem.However, when the SNP density on the genotype panel is not homogeneous, genomic-window based tests can lead to the detection of spurious associations by declaring effects of genomic windows that explain a large proportion of genetic variance as significant.
We propose two methods to solve this problem.